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Literature summary for 6.2.1.5 extracted from

  • Zhao, Y.; Tian, J.; Sui, S.; Yuan, X.; Chen, H.; Qu, C.; Du, Y.; Guo, L.; Du, H.
    Loss of succinyl-CoA synthase ADP-forming ? subunit disrupts mtDNA stability and mitochondrial dynamics in neurons (2017), Sci. Rep., 7, 7169 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.5

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphate + succinyl-CoA Mus musculus
-
 ATP + succinate + CoA
-
 r
ATP + succinate + CoA Mus musculus
-
 ADP + phosphate + succinyl-CoA
-
 r

Organism

Organism UniProt Comment Textmining
Mus musculus Q9Z2I9 subunit beta
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphate + succinyl-CoA
-
 Mus musculus ATP + succinate + CoA
-
 r
ATP + succinate + CoA
-
 Mus musculus ADP + phosphate + succinyl-CoA
-
 r

Subunits

Subunits Comment Organism
? x * 45000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
SCS A-beta
-
 Mus musculus
SCS ADP-forming beta subunit
-
 Mus musculus
succinyl-CoA synthase ADP-forming beta subunit
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
malfunction enzyme deficiency induces severe mitochondrial dysfunction including lowered oxidative phosphorylation efficiency, increased mitochondrial superoxide production, and mitochondrial DNA depletion as well as aberrations of mitochondrial fusion and fission proteins, which eventually leads to neuronal stress Mus musculus