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Literature summary for 6.2.1.49 extracted from
- Regulation of expression of mas and fadD28, two genes involved in production of dimycocerosyl phthiocerol, a virulence factor of Mycobacterium tuberculosis (2002), J. Bacteriol., 184, 6796-6802.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli and Mycobacterium smegmatis | Mycobacterium tuberculosis variant bovis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a long-chain fatty acid + holo-[mycocerosate synthase] | Mycobacterium tuberculosis | - |
AMP + diphosphate + a long-chain acyl-[mycocerosate synthase] | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
| Mycobacterium tuberculosis variant bovis | Q02278 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a long-chain fatty acid + holo-[mycocerosate synthase] | - |
Mycobacterium tuberculosis | AMP + diphosphate + a long-chain acyl-[mycocerosate synthase] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| fadD28 | - |
Mycobacterium tuberculosis |
| fadD28 | - |
Mycobacterium tuberculosis variant bovis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is involved in the synthesis of the virulence factor dimycocerosyl phthiocerol | Mycobacterium tuberculosis variant bovis |
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Release 2023.1 (January 2023)
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