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Literature summary for 6.2.1.45 extracted from

  • Handley, P.M.; Mueckler, M.; Siegel, N.R.; Ciechanover, A.; Schwartz, A.I.
    Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1 (1991), Proc. Natl. Acad. Sci. USA, 88, 258-262.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110450
-
 x * 110450, calculated Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P22314
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information isoform UBA1 mRNA is detected in all tissues analyzed Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information residue Cys194 lies within a region of identity to active-site Cys88 of the ubiquitin carrier protein E2, suggesting a potential role for this region in enzymatic function. Residue Cys454 lies within a region of identity to the thiol ester consensus sequence of several proteins involved in thioester formation Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 110450, calculated Homo sapiens

Synonyms

Synonyms Comment Organism
Uba1
-
 Homo sapiens
ubiquitin-like modifier-activating enzyme 1
-
 Homo sapiens