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Literature summary for 6.2.1.4 extracted from

  • Tsugawa, H.; Suzuki, H.; Nakagawa, I.; Nishizawa, T.; Saito, Y.; Suematsu, M.; Hibi, T.
    Alpha-ketoglutarate oxidoreductase, an essential salvage enzyme of energy metabolism, in coccoid form of Helicobacter pylori (2008), Biochem. Biophys. Res. Commun., 376, 46-51.
    View publication on PubMed
Search for more literature for 6.2.1.4

Inhibitors

Inhibitors Comment Organism Structure
NaI 41% inhibition at 10 mM, the CoAT activity is inhibited by applying NaI to exponentially growing cell cultures, but the colony-forming ability is not affected Helicobacter pylori

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + succinate + CoA Helicobacter pylori succinyl CoA synthetase converts succinyl CoA to succinate in the Krebs cycle. The enzyme activity is reduced, when Helicobacter pylori transforms to the coccoid form, a viable but non-culturable form with reduced metabolic activity, overview GDP + phosphate + succinyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information the enzyme activity is reduced, when Helicobacter pylori transforms to the coccoid form, a viable but non-culturable form with reduced metabolic activity, overview Helicobacter pylori
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + succinate + CoA
-
 Helicobacter pylori GDP + phosphate + succinyl-CoA
-
 ?
GTP + succinate + CoA succinyl CoA synthetase converts succinyl CoA to succinate in the Krebs cycle. The enzyme activity is reduced, when Helicobacter pylori transforms to the coccoid form, a viable but non-culturable form with reduced metabolic activity, overview Helicobacter pylori GDP + phosphate + succinyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
Succinyl CoA synthetase
-
 Helicobacter pylori

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.1
-
 assay at Helicobacter pylori

Cofactor

Cofactor Comment Organism Structure
GTP
-
 Helicobacter pylori