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Literature summary for 6.2.1.3 extracted from

  • Yan, S.; Yang, X.F.; Liu, H.L.; Fu, N.; Ouyang, Y.; Qing, K.
    Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases an update (2015), World J. Gastroenterol., 21, 3492-3498 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.3

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum isoform ACSL3 Mus musculus 5783
-
mitochondrion isoform ACSL5 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a long-chain fatty acid + CoA Mus musculus
-
 AMP + diphosphate + a long-chain acyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P41216
-
-
Mus musculus Q8JZR0
-
-
Mus musculus Q91WC3
-
-
Mus musculus Q9CZW4
-
-
Mus musculus Q9QUJ7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland isoform ACSL4 Mus musculus
-
fetus isoform ACSL3 Mus musculus
-
liver isoform ACSL1 Mus musculus
-
small intestine isoform ACSL5 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a long-chain fatty acid + CoA
-
 Mus musculus AMP + diphosphate + a long-chain acyl-CoA
-
 ?
ATP + arachidonate + CoA preferred substrate of isoform ACSL4 Mus musculus AMP + diphosphate + arachidonoyl-CoA
-
 ?
ATP + docosahexaenoate + CoA preferred substrate of isoform ACSL6 Mus musculus AMP + diphosphate + docosahexaenoyl-CoA
-
 ?
ATP + eicosanoate + CoA preferred substrate of isoform ACSL4 Mus musculus AMP + diphosphate + eicosanoyl-CoA
-
 ?
ATP + oleate + CoA preferred substrate of isoform ACSL3 Mus musculus AMP + diphosphate + oleoyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
ACSL1 isoform Mus musculus
ACSL3 isoform Mus musculus
ACSL4 isoform Mus musculus
ACSL5 isoform Mus musculus
ACSL6 isoform Mus musculus
long-chain acyl-CoA synthetase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
physiological function long-chain acyl-CoA synthetases induce apoptotic cell death via the c-Jun N-terminal kinase pathway Mus musculus