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Literature summary for 6.2.1.3 extracted from

  • Hinder, L.; Figueroa-Romero, C.; Pacut, C.; Hong, Y.; Vivekanandan-Giri, A.; Pennathur, S.; Feldman, E.
    Long-chain acyl coenzyme a synthetase 1 overexpression in primary cultured Schwann cells prevents long chain fatty acid-induced oxidative stress and mitochondrial dysfunction (2014), Antioxid. Redox Signal., 21, 588-600 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a long-chain fatty acid + CoA Rattus norvegicus
-
 AMP + diphosphate + a long-chain acyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P18163
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Schwann cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a long-chain fatty acid + CoA
-
 Rattus norvegicus AMP + diphosphate + a long-chain acyl-CoA
-
 ?
ATP + linoleate + CoA
-
 Rattus norvegicus AMP + diphosphate + linoleoyl-CoA
-
 ?
ATP + oleate + CoA
-
 Rattus norvegicus AMP + diphosphate + oleoyl-CoA
-
 ?
ATP + palmitate + CoA
-
 Rattus norvegicus AMP + diphosphate + palmitoyl-CoA
-
 ?

Subunits

Subunits Comment Organism
? x * 75000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
ACSL1 isoform Rattus norvegicus
long-chain acyl coenzyme A synthetase 1
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function isoform Acsl1 overexpression prevents oxidative stress (nitrotyrosine, hydroxyoctadecadienoic acids) and attenuates cellular injury in Schwann cells following 12 h exposure to long chain fatty acids Rattus norvegicus