Cloned (Comment) | Organism |
---|---|
dACS1, genotyping | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
K294E | naturally occuring mutant of dAcs1, K294E is located in the AMP-binding domain | Drosophila melanogaster |
Q419R | naturally occuring mutant of dAcs1 | Drosophila melanogaster |
W685stop | naturally occuring mutant of dAcs1, W685stop removes the last 33 amino acids | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
isozyme dAcsl | - |
Synonyms | Comment | Organism |
---|---|---|
ACSL | - |
Drosophila melanogaster |
dAcsl | - |
Drosophila melanogaster |
long-chain acyl-CoA synthetase | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
malfunction | abdominal segmentation defects of dAcsl mutants resemble those of gap gene knirps. The central expression domain of Kni transcripts or proteins is reduced whereas the adjacent domains of another gap gene Hunchback are correspondingly expanded in these mutants. Consequently, the striped pattern of the pair-rule gene Even-skipped is disrupted, phenotype, overview | Drosophila melanogaster |
physiological function | dAcsl is the Drosophila homolog of human ACSL4 and their functions are highly conserved in the processes ranging from lipid metabolism to the establishment of visual wiring, both maternal and zygotic dAcsl are required for embryonic segmentation | Drosophila melanogaster |