Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NEM | ACS4 | Rattus norvegicus | |
triacsin | competitive inhibitor of both ACS1 and ACS4 | Rattus norvegicus | |
troglitazone | ACS4 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | ACS1 | Rattus norvegicus | 5829 | - |
endoplasmic reticulum | ACS1 | Rattus norvegicus | 5783 | - |
membrane | mitochondria-associated membrane, ACS1, ACS4 | Rattus norvegicus | 16020 | - |
mitochondrion | mitochondrial membrane, ACS5. ACS1 is not detected in mitochondria | Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | ACS1, ACS4 and ACS5 are regulated independently by fasting and refeeding. Fasting rats for 48 h results in a decrease in ACS4 protein and an increase in ACS5. ACS1 and ACS4 may be functionally channeled to specific metabolic pathways though different ACS isoforms in unique subcellular locations | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + palmitate + CoA | - |
Rattus norvegicus | AMP + diphosphate + palmitoyl-CoA | - |
? | |
additional information | ACS1, ACS4 and ACS5 are regulated independently by fasting and refeeding. Fasting rats for 48 h results in a decrease in ACS4 protein and an increase in ACS5. ACS1 and ACS4 may be functionally channeled to specific metabolic pathways though different ACS isoforms in unique subcellular locations | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACS1 | - |
Rattus norvegicus |
ACS4 | - |
Rattus norvegicus |
ACS5 | - |
Rattus norvegicus |