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Literature summary for 6.2.1.24 extracted from
- Phytanoyl-CoA ligase activity in rat liver (1986), Biochem. Int., 13, 123-130.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | 11 mM, 50% inhibition | Rattus norvegicus |  |
| iodoacetic acid | 75 mM, 100% inhibition | Rattus norvegicus | |
| NEM | 10 mM, 87% inhibition | Rattus norvegicus | |
| palmitic acid | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0286 | - |
phytanic acid | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | absolutely required, optimal concentration: 60 mM, inhibition at high concentrations | Rattus norvegicus | |
| Mn2+ | can replace Mg2+ at 5 mM, inhibition at high concentrations | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
enzyme is different from long chain acyl-CoA ligase, EC 6.2.1.3 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipose tissue | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + phytanate + CoA | - |
Rattus norvegicus | AMP + diphosphate + phytanoyl-CoA | - |
? | |
| CTP + phytanate + CoA | low activity compared to ATP | Rattus norvegicus | CMP + diphosphate + phytanoyl-CoA | - |
? | |
| GTP + phytanate + CoA | low activity compared to ATP | Rattus norvegicus | GMP + diphosphate + phytanoyl-CoA | - |
? | |
| ITP + phytanate + CoA | low activity compared to ATP | Rattus norvegicus | IMP + diphosphate + phytanoyl-CoA | - |
? | |
| UTP + phytanate + CoA | low activity compared to ATP | Rattus norvegicus | UMP + diphosphate + phytanoyl-CoA | - |
? | |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 45 | - |
t1/2: 3-5 min | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.7 | - |
Tris-HCl buffer | Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 11 | - |
AMP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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