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Literature summary for 6.2.1.20 extracted from
- Phosphatidylserine decarboxylase CT699, lysophospholipid acyltransferase CT775, and acyl-ACP synthase CT776 provide membrane lipid diversity to Chlamydia trachomatis (2017), Sci. Rep., 7, 15767 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene slr1609, recombinant expression of enzyme AasC in Escherichia coli | Chlamydia trachomatis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| rosiglitazone | inhibits the enzyme in vivo in recombinant Escherichia coli | Chlamydia trachomatis |  |
| Triacsin C | inhibits the enzyme in vivo in recombinant Escherichia coli | Chlamydia trachomatis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Chlamydia trachomatis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a long-chain fatty acid + an [acyl-carrier protein] | Chlamydia trachomatis | - |
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein] | - |
? | |
| ATP + a long-chain fatty acid + an [acyl-carrier protein] | Chlamydia trachomatis D/UW-3/Cx | - |
AMP + diphosphate + a long-chain acyl-[acyl-carrier protein] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Chlamydia trachomatis | O84781 | in human cells, e.g. HeLa cells | - |
| Chlamydia trachomatis D/UW-3/Cx | O84781 | in human cells, e.g. HeLa cells | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a long-chain fatty acid + an [acyl-carrier protein] | - |
Chlamydia trachomatis | AMP + diphosphate + a long-chain acyl-[acyl-carrier protein] | - |
? | |
| ATP + a long-chain fatty acid + an [acyl-carrier protein] | - |
Chlamydia trachomatis D/UW-3/Cx | AMP + diphosphate + a long-chain acyl-[acyl-carrier protein] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AasC | - |
Chlamydia trachomatis |
| ACP synthase | - |
Chlamydia trachomatis |
| ACSL | - |
Chlamydia trachomatis |
| acyl carrier protein synthase | - |
Chlamydia trachomatis |
| acyl-ACP synthase | - |
Chlamydia trachomatis |
| CT776 | - |
Chlamydia trachomatis |
| slr1609 | - |
Chlamydia trachomatis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | 37 | in vivo assay at in recombinant Escherichia coli | Chlamydia trachomatis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Chlamydia trachomatis | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | fatty acid incorporation by Chlamydia-infected cells and Chlamydia AasC activity is inhibited by triacsin C and rosiglitazoneG | Chlamydia trachomatis |
| metabolism | phosphatidylserine decarboxylase CT699, lysophospholipid acyltransferase CT775, and acyl-ACP synthase CT776 provide membrane lipid diversity to Chlamydia trachomatis | Chlamydia trachomatis |
| physiological function | in infected cells, incorporation of exogenous long-chain fatty acids into membrane glycerophospholipids proceeds by their esterification to acyl-CoA by human long-chain acyl-CoA synthetase (hACSL) enzymes and to acyl-ACP by the bacterial acyl carrier protein (ACP) synthase AasC (CT776) | Chlamydia trachomatis |
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