Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diflunisal | 0.001 mM, complete inhibition | Bos taurus | |
diflunisal | 0.001 mM, complete inhibition | Mus musculus | |
enoxacin | - |
Bos taurus | |
enoxacin | - |
Mus musculus | |
Nalidixic acid | 0.001 mM, complete inhibition | Bos taurus | |
Nalidixic acid | 0.001 mM, complete inhibition | Mus musculus | |
ofloxacine | - |
Bos taurus | |
ofloxacine | - |
Mus musculus | |
salicylic acid | 0.001 mM, complete inhibition | Bos taurus | |
salicylic acid | 0.001 mM, complete inhibition | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Bos taurus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
65000 | - |
SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Sephadex G-25 gel filtration, DEAE-Sepharose column chromatography, and hydroxylapatite column chromatography | Mus musculus |
Sephadex G-25 gel filtration, DEAE-Sepharose column chromatography, and hydroxylapatite column chromatography | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.023 | - |
cell extract, with 0.001 mM hexanoic acid as a substrate in 0.2 M Tris-HCl buffer (pH 8.5) | Mus musculus |
4.14 | - |
after 180fold purification, with 0.001 mM hexanoic acid as a substrate in 0.2 M Tris-HCl buffer (pH 8.5) | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-naphthoic acid + CoA | - |
Mus musculus | AMP + diphosphate + 1-naphthoyl-CoA | - |
? | |
ATP + 1-naphthoic acid + CoA | - |
Bos taurus | AMP + diphosphate + 1-naphthoyl-CoA | - |
? | |
ATP + 1-naphthylacetic acid + CoA | - |
Mus musculus | AMP + diphosphate + 1-naphthylacetoyl-CoA | - |
? | |
ATP + 1-naphthylacetic acid + CoA | - |
Bos taurus | AMP + diphosphate + 1-naphthylacetoyl-CoA | - |
? | |
ATP + 3-methylbenzoate + CoA | - |
Mus musculus | AMP + diphosphate + 3-methylbenzoyl-CoA | - |
? | |
ATP + 3-methylbenzoate + CoA | - |
Bos taurus | AMP + diphosphate + 3-methylbenzoyl-CoA | - |
? | |
ATP + 4-methylbenzoate + CoA | - |
Mus musculus | AMP + diphosphate + 4-methylbenzoyl-CoA | - |
? | |
ATP + 4-methylbenzoate + CoA | - |
Bos taurus | AMP + diphosphate + 4-methylbenzoyl-CoA | - |
? | |
ATP + benzoate + CoA | high activities are obtained with benzoate having methyl, pentyl, and methoxy groups in the para- or meta-positions of the benzene ring | Mus musculus | AMP + diphosphate + benzoyl-CoA | - |
? | |
ATP + benzoate + CoA | high activities are obtained with benzoate having methyl, pentyl, and methoxy groups in the para- or meta-positions of the benzene ring | Bos taurus | AMP + diphosphate + benzoyl-CoA | - |
? | |
ATP + decanoate + CoA | - |
Mus musculus | AMP + diphosphate + decanoyl-CoA | - |
? | |
ATP + decanoate + CoA | - |
Bos taurus | AMP + diphosphate + decanoyl-CoA | - |
? | |
ATP + hexanoate + CoA | maximal activity on hexanoate | Mus musculus | AMP + diphosphate + hexanoyl-CoA | - |
? | |
ATP + hexanoate + CoA | maximal activity on hexanoate | Bos taurus | AMP + diphosphate + hexanoyl-CoA | - |
? | |
ATP + ketoprofen + CoA | less active on ketoprofen | Mus musculus | ADP + diphosphate + ? | - |
? | |
ATP + ketoprofen + CoA | less active on ketoprofen | Bos taurus | ADP + diphosphate + ? | - |
? | |
ATP + m-methoxybenzoate + CoA | - |
Mus musculus | AMP + diphosphate + m-methoxybenzoyl-CoA | - |
? | |
ATP + m-methoxybenzoate + CoA | - |
Bos taurus | AMP + diphosphate + m-methoxybenzoyl-CoA | - |
? | |
ATP + m-pentylbenzoate + CoA | - |
Mus musculus | AMP + diphosphate + m-pentylbenzoyl-CoA | - |
? | |
ATP + m-pentylbenzoate + CoA | - |
Bos taurus | AMP + diphosphate + m-pentylbenzoyl-CoA | - |
? | |
ATP + octanoate + CoA | - |
Mus musculus | AMP + diphosphate + octanoyl-CoA | - |
? | |
ATP + octanoate + CoA | - |
Bos taurus | AMP + diphosphate + octanoyl-CoA | - |
? | |
ATP + p-methoxybenzoate + CoA | - |
Mus musculus | AMP + diphosphate + p-methoxybenzoyl-CoA | - |
? | |
ATP + p-methoxybenzoate + CoA | - |
Bos taurus | AMP + diphosphate + p-methoxybenzoyl-CoA | - |
? | |
ATP + p-pentylbenzoate + CoA | - |
Mus musculus | AMP + diphosphate + p-pentylbenzoyl-CoA | - |
? | |
ATP + p-pentylbenzoate + CoA | - |
Bos taurus | AMP + diphosphate + p-pentylbenzoyl-CoA | - |
? | |
ATP + valproate + CoA | less active on valproate | Mus musculus | ADP + diphosphate + valproyl-CoA | - |
? | |
ATP + valproate + CoA | less active on valproate | Bos taurus | ADP + diphosphate + valproyl-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
medium chain acyl-CoA synthetase | - |
Mus musculus |
medium chain acyl-CoA synthetase | - |
Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0237 | - |
enoxacin | - |
Mus musculus | |
0.0382 | - |
ofloxacine | - |
Mus musculus |