Any feedback?
Literature summary for 6.2.1.2 extracted from
- Inhibitory effect of quinolone antimicrobial and nonsteroidal anti-inflammatory drugs on a medium chain acyl-CoA synthetase (2001), Biochem. Pharmacol., 62, 363-367.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-hydroxydodecanoic acid | competitive; potent | Mus musculus |  |
| 2-Hydroxynaphthoic acid | competitive; potent | Mus musculus | |
| diflunisal | competitive; potent | Mus musculus | |
| enoxacin | potent, mixed-type inhibition | Mus musculus | |
| felbinac | inhibits activity with hexanoic acid, IC50: 0.025 mM | Mus musculus | |
| Nalidixic acid | competitive; potent | Mus musculus | |
| ofloxacin | potent, mixed-type inhibition | Mus musculus | |
| salicylic acid | competitive; potent | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme catalyzes the first reaction of glycine conjugation | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + hexanoate + CoA | 15% of the activity with octanoate | Mus musculus | AMP + diphosphate + hexanoyl-CoA | - |
? | |
| additional information | the enzyme catalyzes the first reaction of glycine conjugation | Mus musculus | ? | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0006 | - |
diflunisal | pH 8.5, 37°C | Mus musculus | |
| 0.0124 | - |
Nalidixic acid | pH 8.5, 37°C | Mus musculus | |
| 0.0134 | - |
2-Hydroxynaphthoic acid | pH 8.5, 37°C | Mus musculus | |
| 0.015 | - |
2-hydroxydodecanoic acid | pH 8.5, 37°C | Mus musculus | |
| 0.0196 | - |
salicylic acid | pH 8.5, 37°C | Mus musculus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.025 | - |
inhibits activity with hexanoic acid, IC50: 0.025 mM | Mus musculus | felbinac | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
