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Literature summary for 6.2.1.17 extracted from

  • Ricks, C.A.; Cook, R.M.
    Regulation of volatile fatty acid uptake by mitochondrial acyl CoA synthetases of bovine liver (1981), J. Dairy Sci., 64, 2324-2335.
    View publication on PubMed
Search for more literature for 6.2.1.17

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.63
-
 CoA
-
 Bos taurus
1.3
-
 propanoate ATP, propanoate Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 2 * 35000, SDS-PAGE Bos taurus
73400
-
 sucrose density gradient centrifugation Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + propanoate + CoA Bos taurus the distinct propionyl CoA synthetase regulated by the concentration of propanoate in portal blood is significant because a primary role of ruminant liver is to synthesize glucose from ruminally derived propanoate ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.36
-
-
 Bos taurus

Storage Stability

Storage Stability Organism
-20°C, 10% glycerol, stable for months Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetate + CoA no activity Bos taurus AMP + diphosphate + acetyl-CoA
-
 ?
ATP + acrylate + CoA 85% of the activity relative to propanoate Bos taurus AMP + diphosphate + acryloyl-CoA
-
 ?
ATP + butyrate + CoA no activity Bos taurus AMP + diphosphate + butyryl-CoA
-
 ?
ATP + crotonate + CoA 13% of the activity relative to propanoate Bos taurus AMP + diphosphate + crotonyl-CoA
-
 ?
ATP + propanoate + CoA
-
 Bos taurus AMP + diphosphate + propanoyl-CoA
-
 ?
ATP + propanoate + CoA the distinct propionyl CoA synthetase regulated by the concentration of propanoate in portal blood is significant because a primary role of ruminant liver is to synthesize glucose from ruminally derived propanoate Bos taurus ?
-
 ?
ATP + salicylate + CoA 8% of the activity relative to propanoate Bos taurus AMP + diphosphate + salicyl-CoA
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 35000, SDS-PAGE Bos taurus