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Literature summary for 6.2.1.17 extracted from
- Propionyl-CoA synthetase in mammary gland and liver of cows (1991), Rev. Esp. Fisiol., 47, 63-68.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | substrate inhibition at high concentrations, above 20 mM for the liver enzyme and above 10 mM for the mammary gland enzyme | Bos taurus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.9 | - |
CoA | cow liver enzyme | Bos taurus | |
| 1 | - |
CoA | mammary gland enzyme, cow | Bos taurus | |
| 1.1 | - |
ATP | mammary gland enzyme, cow | Bos taurus | |
| 1.3 | - |
propanoate | mamary gland enzyme, cow, | Bos taurus | |
| 4.8 | - |
ATP | cow liver enzyme | Bos taurus | |
| 5.3 | - |
propanoate | cow liver enzyme | Bos taurus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Bos taurus | |
| Mg2+ | Km: 5.5 mM for cow liver enzyme, Km: 1.6 mM for mammary gland enzyme | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf and midlactation cow | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
| mammary gland | of midlactation cow, no activity in calf | Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetate + CoA | 22% of the activity relative to propanonate | Bos taurus | AMP + diphosphate + acetyl-CoA | - |
? | |
| ATP + butyrate + CoA | 27% of the activity relative to propanoate | Bos taurus | AMP + diphosphate + butyryl-CoA | - |
? | |
| ATP + propanoate + CoA | - |
Bos taurus | AMP + diphosphate + propanoyl-CoA | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
cow liver enzyme | Bos taurus |
| 50 | - |
mammary gland enzyme, cow | Bos taurus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
- |
30 | 5 min, maximal stability, cow liver and mammary gland enzymes | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | cow liver enzyme | Bos taurus |
| 8 | 9 | mammary gland enzyme, cow | Bos taurus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 8 | 9 | cow liver enzyme | Bos taurus |
| 8.5 | 9 | mammary gland enzyme, cow | Bos taurus |
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Release 2023.1 (January 2023)
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