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Literature summary for 6.2.1.1 extracted from

  • Schug, Z.T.; Peck, B.; Jones, D.T.; Zhang, Q.; Grosskurth, S.; Alam, I.S.; Goodwin, L.M.; Smethurst, E.; Mason, S.; Blyth, K.; McGarry, L.; James, D.; Shanks, E.; Kalna, G.; Saunders, R.E.; Jiang, M.; Howell, M.; Lassailly, F.; Thin, M.Z.; Spencer-Dene, B.; Stamp, G.; van den Broek, N.J.; Mackay, G.; Bulusu, V.; Kamphorst, J.J.; Tardito, S.; Strachan, D.; Harris, A.L.; Aboagye, E.O.; Critchlow, S.E.; Wakelam, M.J.; Schulze, A.; Gottlieb, E.
    Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress (2015), Cancer Cell, 27, 57-71 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetate + CoA Homo sapiens
-
AMP + diphosphate + acetyl-CoA
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NR19
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast tumor cell
-
Homo sapiens
-
BT-474 cell
-
Homo sapiens
-
DU-145 cell
-
Homo sapiens
-
prostate cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetate + CoA
-
Homo sapiens AMP + diphosphate + acetyl-CoA
-
?

Synonyms

Synonyms Comment Organism
acetyl-CoA synthetase 2
-
Homo sapiens
ACSS2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is frequently upregulated in cancer. Hypoxia and low-serum culture conditions synergistically enhance isoforms ACSS2 expression up