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Literature summary for 6.2.1.1 extracted from
- Role of acetyl-coenzyme A synthetase in leaves of Arabidopsis thaliana (2002), Arch. Biochem. Biophys., 402, 259-267.
General Stability
| General Stability | Organism |
|---|---|
| KCl stabilizes | Pisum sativum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | competitive to CoASH | Pisum sativum |  |
| ADP | competitive to ATP | Pisum sativum | |
| AMP | competitive to ATP | Pisum sativum | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.026 | - |
acetyl-CoA | pH 8.0 | Pisum sativum | |
| 0.16 | - |
acetate | pH 8.0 | Pisum sativum | |
| 0.52 | - |
ATP | pH 8.0 | Pisum sativum | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | MgATP2- is the actual substrate | Pisum sativum | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetate + CoA | Arabidopsis thaliana | no relationship between the enzyme level and the capacity of the plants to incorporate CO2 into labeled fatty acids. Very limited role of the enzyme in the biosynthesis of lipids | AMP + diphosphate + acetyl-CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
| Pisum sativum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | from plants with altered ACS levels | Arabidopsis thaliana | - |
| shoot | - |
Pisum sativum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + acetate + CoA | - |
Pisum sativum | AMP + diphosphate + acetyl-CoA | - |
? | |
| ATP + acetate + CoA | - |
Arabidopsis thaliana | AMP + diphosphate + acetyl-CoA | - |
? | |
| ATP + acetate + CoA | no relationship between the enzyme level and the capacity of the plants to incorporate CO2 into labeled fatty acids. Very limited role of the enzyme in the biosynthesis of lipids | Arabidopsis thaliana | AMP + diphosphate + acetyl-CoA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACS | - |
Pisum sativum |
| ACS | - |
Arabidopsis thaliana |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.3 | 10.2 | in 25 mM KCl buffer | Pisum sativum |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | 10.1 | about 50% of maximal activity at pH 6.8 and pH 10.1 | Pisum sativum |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.7 | - |
acetyl-CoA | pH 8.0 | Pisum sativum | |
| 12 | - |
ADP | pH 8.0 | Pisum sativum | |
| 15 | - |
AMP | pH 8.0 | Pisum sativum | |
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Release 2023.1 (January 2023)
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