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Literature summary for 6.1.2.1 extracted from
- D-AlaD-X ligases: evaluation of D-alanyl phosphate intermediate by MIX, PIX and rapid quench studies (2000), Chem. Biol., 7, 505-514.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterococcus faecium | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Ala + D-lactate + ATP | - |
Enterococcus faecium | D-Ala-D-lactate + ADP + phosphate | - |
? |  |
| additional information | reaction proceeds via rapid and reversible formation of the enzyme intermediate D-Ala-phosphate. Reversible cleavage of ATP to ADP and D-Ala-phosphate and reformation of ATP are detectable. D-Ala-phosphate is a common intermediate that serves as the electrophilic substrate in the condensation with D-Lac as nucleophilic cosubstrate | Enterococcus faecium | ? | - |
? | |
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