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Literature summary for 6.1.1.9 extracted from
- Redundancy of non-AUG initiators. A clever mechanism to enhance the efficiency of translation in yeast (2006), J. Biol. Chem., 281, 7775-7783.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene VAS1, codes for both cytoplasmic and mitochondrial isozymes of ValRS through alternative transcription and translation, expression of wild-type and mutant enzymes in yeast | Saccharomyces cerevisiae |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | substitution of the AUG initiator of the mitochondrial ValRS isozyme, ATG1 of VAS1, with redundant ACG triplets, mutation of ATG1 to GCG deprived the construct of its mitochondrial activity, redundant ACG triplets could effectively substitute for ATG1 in initiation of the mitochondrial enzyme, while a single ACG triplet could hardly do so | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
| mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Saccharomyces cerevisiae |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-valine + tRNAVal | Saccharomyces cerevisiae | - |
AMP + diphosphate + L-valyl-tRNAVal | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
gene VAS1, cytoplasmic and mitochondrial isozymes | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-valine + tRNAVal | - |
Saccharomyces cerevisiae | AMP + diphosphate + L-valyl-tRNAVal | - |
? | |
| additional information | redundancy of non-AUG initiators is a mechanism to enhance the efficiency of translation in yeast | Saccharomyces cerevisiae | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Valyl-tRNA synthetase | - |
Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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