Literature summary for 6.1.1.6 extracted from

Singh, I.; Yadav, A.R.; Mohanty, K.K.; Katoch, K.; Sharma, P.; Mishra, B.; Bisht, D.; Gupta, U.D.; Sengupta, U.
Molecular mimicry between Mycobacterium leprae proteins (50S ribosomal protein L2 and lysyl-tRNA synthetase) and myelin basic protein a possible mechanism of nerve damage in leprosy (2015), Microbes Infect., 17, 247-257 .

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Organism

Organism	UniProt	Comment	Textmining
Mycobacterium leprae	-	bacilli derived from Armadillo liver	-

Synonyms

Synonyms	Comment	Organism
lysyl tRNA synthetase	-	Mycobacterium leprae
Lysyl-tRNA synthetase	-	Mycobacterium leprae

General Information

General Information	Comment	Organism
additional information	similarity between the predicted B cell epitopes of 20 kDa microtubule-stabilizing protein of Bos taurus, MBP (MBP98-104), and 50S ribosomal protein L2 or lysyl-tRNA synthetase of Mycobacterium leprae. Two B cell epitopes of MBP98-104 with 50S ribosomal protein L2226-237 and MBP127-131 and MBP55-60 with 50S ribosomal protein L2 of Mycobacterium leprae41-46 are mimicking epitopes. While, 2 B cell epitopes of MBP85-98 with lysyl tRNA synthetase388-401 and MBP99-104 with lysyl tRNA synthetase472-477 are mimicking with each other	Mycobacterium leprae
physiological function	four B cell epitopes of myelin A1 and Mycobacterium leprae proteins, 50S ribosomal L2 and lysyl tRNA synthetase are cross-reactive. Further, Mycobacterium leprae sonicated antigen hyperimmunization is responsible for induction of autoantibody response in mice. Role of molecular mimicry in nerve damage in leprosy	Mycobacterium leprae

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Release 2023.1 (January 2023)