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Literature summary for 6.1.1.6 extracted from

  • Kim, B.H.; Jung, W.Y.; Lee, H.; Kang, Y.; Jang, Y.J.; Hong, S.W.; Jeong, H.J.; Yoon, S.O.
    Lysyl-tRNA synthetase (KRS) expression in gastric carcinoma and tumor-associated inflammation (2014), Ann. Surg. Oncol., 21, 2020-2027 .
    View publication on PubMed
Search for more literature for 6.1.1.6

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
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 Homo sapiens 5737
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Organism

Organism UniProt Comment Textmining
Homo sapiens Q15046
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric cancer cell high expression of KRS in tumor cells is noted in 43.3 % (198 of 457) of the cases. High expression of KRS in tumor-associated inflammatory cells including macrophages/monocytes, CD4-positive T cells, and/or neutrophils is observed in 37.2 % (170 of 457) of the cases, overview Homo sapiens
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gastric carcinoma cell KRS protein is expressed with a fine granular pattern in the cytoplasm of the tumor cells Homo sapiens
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Synonyms

Synonyms Comment Organism
KRS
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 Homo sapiens
Lysyl-tRNA synthetase
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 Homo sapiens

General Information

General Information Comment Organism
malfunction aberrant expression of aminoacyl-tRNA synthetases is associated with various human cancers. Enzyme status and clinicopathological parameters reveal that the enzyme expression is correlated with a shorter overall survival. Enzyme KRS has an oncogenic role, it binds microphthalmia-associated transcription factor (MITF), which is an oncogenic transcriptional activator observed in the development of melanoma Homo sapiens
metabolism lysyl-tRNA synthetase (KRS) is one component of multisynthetase complex that consists of eight aminoacyl-tRNA synthetases and three nonenzymatic factors known as ARS-interacting multifunctional protein Homo sapiens
physiological function lysyl-tRNA synthetase (KRS) is an aminoacyl-tRNA synthetase (ARS) that is essential for protein synthesis during ligation of specific amino acids to their cognate tRNAs Homo sapiens