Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
in complex with p38/AIMP2 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S270D | the mutant shows 800fold enhanced catalytic activity compared to the wild type enzyme, with enhanced diadenosine tetraphosphate synthetic activity, enhanced ATP hydrolysis and lost aminoacylation activity for tRNALys | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-lysine + tRNALys | Homo sapiens | - |
AMP + diphosphate + L-lysyl-tRNALys | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | Ser207-phosphorylation inactivates the enzyme translationally, but activates its transcriptional function | Homo sapiens |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-lysine + tRNALys | - |
Homo sapiens | AMP + diphosphate + L-lysyl-tRNALys | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LysRS | - |
Homo sapiens |
Lysyl-tRNA synthetase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |