Literature summary for 6.1.1.6 extracted from

Yannay-Cohen, N.; Carmi-Levy, I.; Kay, G.; Yang, C.M.; Han, J.M.; Kemeny, D.M.; Kim, S.; Nechushtan, H.; Razin, E.
LysRS serves as a key signaling molecule in the immune response by regulating gene expression (2009), Mol. Cell, 34, 603-611.

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Cloned(Commentary)

Cloned (Comment)	Organism
transfection of RBL-2H3 cell	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	in response to immunological challenge of mast cells, LysRS is phosphorylated on residue Ser207 in a MAPK-dependent manner, released from the multisynthetase complex, and translocated into the nucleus	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	in response to immunological challenge of mast cells, LysRS is phosphorylated on residue Ser207 in a MAPK-dependent manner, released from the multisynthetase complex, and translocated into the nucleus	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	silencing of LysRS leads to reduced Ap4P production in immunologically activated cells, which results in a lower level of MITF inducible genes. Specific LysRS Ser207 phosphorylation regulates Ap4P production in immunologically stimulated mast cells	Homo sapiens

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Release 2023.1 (January 2023)