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Literature summary for 6.1.1.6 extracted from

  • Chou, T.F.; Wagner, C.R.
    Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins (2007), J. Biol. Chem., 282, 4719-4727.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Diphosphatase
-
Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
Zn2+
-
Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens
Mg2+ 1.5 mM, required Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+-agarose column chromatography Escherichia coli
Ni2+-agarose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-lysine + tRNALys
-
Escherichia coli AMP + L-lysyl-tRNALys + diphosphate
-
r
ATP + L-lysine + tRNALys
-
Homo sapiens AMP + L-lysyl-tRNALys + diphosphate
-
r

Synonyms

Synonyms Comment Organism
LysRS
-
Homo sapiens
LysU
-
Escherichia coli
Lysyl-tRNA synthetase
-
Escherichia coli
Lysyl-tRNA synthetase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Escherichia coli
ATP
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.015
-
-
Escherichia coli Zn2+