Cloned (Comment) | Organism |
---|---|
gene ileS, quantitative real-time PCR expression analysis | Salmonella enterica |
Protein Variants | Comment | Organism |
---|---|---|
P184T | naturally occuring mutation that restores fitness in mupirocin resistant strains | Salmonella enterica |
Q420H | naturally occuring mutation that restores fitness in mupirocin resistant strains | Salmonella enterica |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
mupirocin | Mup, an isoleucyl-adenylate analogue that inhibits the essential enzyme, isoleucyl-tRNA synthetase | Salmonella enterica |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica | - |
gene ileS | - |
Synonyms | Comment | Organism |
---|---|---|
IleRS | - |
Salmonella enterica |
Isoleucyl-tRNA synthetase | - |
Salmonella enterica |
General Information | Comment | Organism |
---|---|---|
additional information | in mupirocin-resistant strains, e.g. evolved strain C12 that carried several copies of ileS, the antibiotic resistance leads also to reduced growth rates, these can be restored by the organism via increased expression of the original mutant ileS gene, also improving fitness while maintaining resistance, a process of adaptation initiated by common amplifications and followed by later acquisition of rare point mutations. A point mutation in one copy relaxes selection and allows loss of defective ileS copies, overview. Model for genetic adaptation of cells to the growth limitation caused by their MupR, overview | Salmonella enterica |