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Literature summary for 6.1.1.5 extracted from
- Insights into editing from an Ile-tRNA synthetase structure with tRNAIle and mupirocin (1999), Science, 285, 1074-1077.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| purified recombinant enzyme cocrystallized with Escherichia coli tRNAIle and inhibitor muciproin, formation of the socalled editing complex, X-ray diffraction structure determination at 2.2 A resolution, and structure analysis | Staphylococcus aureus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| muciproin | - |
Staphylococcus aureus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-isoleucine + tRNAIle | Staphylococcus aureus | - |
AMP + diphosphate + L-isoleucyl-tRNAIle | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | P41972 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle | active site structure and mechanism | Staphylococcus aureus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-isoleucine + tRNAIle | - |
Staphylococcus aureus | AMP + diphosphate + L-isoleucyl-tRNAIle | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IleRS | - |
Staphylococcus aureus |
| IRS | - |
Staphylococcus aureus |
| Isoleucine translase | - |
Staphylococcus aureus |
| Isoleucine--tRNA ligase | - |
Staphylococcus aureus |
| Isoleucine-transfer RNA ligase | - |
Staphylococcus aureus |
| Isoleucine-tRNA synthetase | - |
Staphylococcus aureus |
| Isoleucyl-transfer ribonucleate synthetase | - |
Staphylococcus aureus |
| Isoleucyl-transfer RNA synthetase | - |
Staphylococcus aureus |
| Isoleucyl-tRNA synthetase | - |
Staphylococcus aureus |
| Mupirocin resistance protein | - |
Staphylococcus aureus |
| Synthetase, isoleucyl-transfer ribonucleate | - |
Staphylococcus aureus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Staphylococcus aureus | |
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Release 2023.1 (January 2023)
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