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Literature summary for 6.1.1.4 extracted from

  • Han, J.M.; Jeong, S.J.; Park, M.C.; Kim, G.; Kwon, N.H.; Kim, H.K.; Ha, S.H.; Ryu, S.H.; Kim, S.
    Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway (2012), Cell, 149, 410-424.
    View publication on PubMed
Search for more literature for 6.1.1.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-leucine + tRNALeu Homo sapiens
-
 AMP + diphosphate + L-leucyl-tRNALeu
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-leucine + tRNALeu
-
 Homo sapiens AMP + diphosphate + L-leucyl-tRNALeu
-
 ?

Synonyms

Synonyms Comment Organism
Leucyl-tRNA synthetase
-
 Homo sapiens
LRS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme plays a critical role in amino acid-induced mammalian target of rapamycin C1 activation by sensing intracellular leucine concentration and initiating molecular events leading to mammalian target of rapamycin C1 activation. The enzyme directly binds to Rag GTPase, the mediator of amino acid signaling to mTORC1, in an amino acid-dependent manner and functions as a GTPase-activating protein for Rag GTPase to activate mammalian target of rapamycin C1 Homo sapiens