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Literature summary for 6.1.1.22 extracted from

  • D, J.J.; Dhanraj, M.; Solaiappan, S.; Sivanesan, S.; Kron, M.; Dhanasekaran, A.
    Brugia malayi asparaginyl-tRNA synthetase stimulates endothelial cell proliferation, vasodilation and angiogenesis (2016), PLoS ONE, 11, e0146132 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.22

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Brugia malayi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-asparagine + tRNAAsn Brugia malayi
-
 AMP + diphosphate + L-asparaginyl-tRNAAsn
-
 ?

Organism

Organism UniProt Comment Textmining
Brugia malayi
-
-
-

Purification (Commentary)

Purification (Comment) Organism
immobilized metal-affinity chromatography Brugia malayi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-asparagine + tRNAAsn
-
 Brugia malayi AMP + diphosphate + L-asparaginyl-tRNAAsn
-
 ?

Subunits

Subunits Comment Organism
? x * 63000, His6-tagged enzyme, SDS-PAGE Brugia malayi

Synonyms

Synonyms Comment Organism
AsnRS
-
 Brugia malayi
Asparaginyl-tRNA synthetase
-
 Brugia malayi

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Brugia malayi

General Information

General Information Comment Organism
physiological function the enzyme induces endothelial cell proliferation, promotes chemotaxis and induces ring formation and tube formation by EA.hy926 cells. The enzyme induces vasodilation in chick embryo chorioallantoic membranes Brugia malayi