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Literature summary for 6.1.1.22 extracted from

  • Yu, Z.; Vodanovic-Jankovic, S.; Ledeboer, N.; Huang, S.X.; Rajski, S.R.; Kron, M.; Shen, B.
    Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase (2011), Org. Lett., 13, 2034-2037.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.22

Inhibitors

Inhibitors Comment Organism Structure
tirandamycin A selective inhibitor Brugia malayi
tirandamycin B selective inhibitor Brugia malayi
tirandamycin E selective inhibitor Brugia malayi
tirandamycin F selective inhibitor Brugia malayi
tirandamycin G selective inhibitor Brugia malayi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-asparagine + tRNAAsn Brugia malayi
-
 AMP + diphosphate + L-asparaginyl-tRNAAsn
-
 ?

Organism

Organism UniProt Comment Textmining
Brugia malayi
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-asparagine + tRNAAsn
-
 Brugia malayi AMP + diphosphate + L-asparaginyl-tRNAAsn
-
 ?

Synonyms

Synonyms Comment Organism
AsnRS
-
 Brugia malayi
asparagine tRNA synthetase
-
 Brugia malayi
Asparaginyl-tRNA synthetase
-
 Brugia malayi

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Brugia malayi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.03
-
 pH and temperature not specified in the publication Brugia malayi tirandamycin G