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Literature summary for 6.1.1.22 extracted from

  • Crepin, T.; Peterson, F.; Haertlein, M.; Jensen, D.; Wang, C.; Cusack, S.; Kron, M.
    A hybrid structural model of the complete Brugia malayi cytoplasmic asparaginyl-tRNA synthetase (2011), J. Mol. Biol., 405, 1056-1069.
    View publication on PubMed
Search for more literature for 6.1.1.22

Crystallization (Commentary)

Crystallization (Comment) Organism
purified apo-AsnRS, AsnRS in complex with AsnAMS, and in complex with Mg2+, ATP, and l-Asp-beta-NOH, X-ray diffraction structure determination and analysis at 1.9-2.4 A resolution Brugia malayi

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Brugia malayi 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Brugia malayi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-asparagine + tRNAAsn Brugia malayi
-
 AMP + diphosphate + L-asparaginyl-tRNAAsn
-
 ?

Organism

Organism UniProt Comment Textmining
Brugia malayi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-asparagine + tRNAAsn
-
 Brugia malayi AMP + diphosphate + L-asparaginyl-tRNAAsn
-
 ?
ATP + L-asparagine + tRNAAsn AsnRS structure analysis shows binding of Mg2+-ATP in one active site and L-Asp-beta-NOH adenylate and Mg2+-diphosphate in the other active site. Active-site ordering and rearrangement during activation, overview. The AsnRSBm N-terminal extension binds tRNA, structure, overview Brugia malayi AMP + diphosphate + L-asparaginyl-tRNAAsn
-
 ?

Subunits

Subunits Comment Organism
More X-ray crystallography and NMR structure determination and analysis of full-length and catalytically active N-terminally truncated enzyme, DELTAAsnRSBm monomer, comprising residues 112-548, overview Brugia malayi

Synonyms

Synonyms Comment Organism
AsnRS
-
 Brugia malayi
Asparaginyl-tRNA synthetase
-
 Brugia malayi
class IIb asparaginyl-tRNA synthetase
-
 Brugia malayi

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Brugia malayi