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Literature summary for 6.1.1.22 extracted from
- Fibroblast growth factor 2-induced cytoplasmic asparaginyl-tRNA synthetase promotes survival of osteoblasts by regulating anti-apoptotic PI3K/Akt signaling (2009), Bone, 45, 994-1003.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| NARS, transient transfection of MC3T3-E1 cells and primary mouse calvarial cells | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | downregulation of NARS by siRNA in MC3T3-E1 and primary mouse calvarial cells | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Mus musculus | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 65000 | - |
x * 65000, SDS-PAGE | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| osteoblast | - |
Mus musculus | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 65000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Asparaginyl-tRNA synthetase | - |
Mus musculus |
| More | the enzyme belongs to the aminoacyl-tRNA synthetase family, AARS | Mus musculus |
| NARS | - |
Mus musculus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Mus musculus | isoelectric focusing | - |
5.8 |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | fibroblast growth factor 2, FGF2, that functions in intracellular signaling in bone development, induces the enzyme in MC3T3-E1 preosteoblast cells more than 900fold, the overexpression of NARS significantly increases the proliferation of both the MC3T3-E1 and the primary mouse calvarial cells, overview | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | asparaginyl-tRNA synthetase is a member of the class-II aminoacyl-tRNA synthetases, and is responsible for catalyzing the specific aminoacylation of tRNAAsn with asparagine | Mus musculus |
| physiological function | NARS is one of the important mediators of FGF2 induced survival signaling in osteoblasts through the activation of PI3K/Akt survival pathway | Mus musculus |
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Release 2023.1 (January 2023)
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