Literature summary for 6.1.1.21 extracted from

Zhou, J.J.; Wang, F.; Xu, Z.; Lo, W.S.; Lau, C.F.; Chiang, K.P.; Nangle, L.A.; Ashlock, M.A.; Mendlein, J.D.; Yang, X.L.; Zhang, M.; Schimmel, P.
Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis (2014), J. Biol. Chem., 289, 19269-19275 .

Search for more literature for 6.1.1.21

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-histidine + tRNAHis	Homo sapiens	-	AMP + diphosphate + L-histidyl-tRNAHis	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA column chromatography and Superdex 200 gel filtration	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipose tissue	-	Homo sapiens	-
bone marrow	-	Homo sapiens	-
colon	-	Homo sapiens	-
heart	-	Homo sapiens	-
kidney	-	Homo sapiens	-
leukocyte	-	Homo sapiens	-
liver	-	Homo sapiens	-
lung	-	Homo sapiens	-
pancreas	-	Homo sapiens	-
skeletal muscle	-	Homo sapiens	-
small intestine	-	Homo sapiens	-
spleen	-	Homo sapiens	-
thyroid gland	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-histidine + tRNAHis	-	Homo sapiens	AMP + diphosphate + L-histidyl-tRNAHis	-	?

Subunits

Subunits	Comment	Organism
?	x * 55000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
HARS	-	Homo sapiens
HisRS	-	Homo sapiens
Histidyl-tRNA synthetase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)