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Literature summary for 6.1.1.21 extracted from

  • Englert, M.; Vargas-Rodriguez, O.; Reynolds, N.M.; Wang, Y.S.; Soell, D.; Umehara, T.
    A genomically modified Escherichia coli strain carrying an orthogonal E. coli histidyl-tRNA synthetase tRNAHis pair (2017), Biochim. Biophys. Acta, 1861, 3009-3015 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.21

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli MEOV1 cells Caulobacter vibrioides

Protein Variants

Protein Variants Comment Organism
E131A inactive Caulobacter vibrioides
Y264A inactive Caulobacter vibrioides

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-histidine + tRNAHis Caulobacter vibrioides
-
 AMP + diphosphate + L-histidyl-tRNAHis
-
 ?

Organism

Organism UniProt Comment Textmining
Caulobacter vibrioides
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-methyl-L-histidine + tRNAHis
-
 Caulobacter vibrioides AMP + diphosphate + 1-methyl-L-histidyl-tRNAHis
-
 ?
ATP + 2-thio-L-histidine + tRNAHis low activity Caulobacter vibrioides AMP + diphosphate + 2-thio-L-histidyl-tRNAHis
-
 ?
ATP + 3-methyl-L-histidine + tRNAHis
-
 Caulobacter vibrioides AMP + diphosphate + 3-methyl-L-histidyl-tRNAHis
-
 ?
ATP + D-histidine + tRNAHis
-
 Caulobacter vibrioides AMP + diphosphate + D-histidyl-tRNAHis
-
 ?
ATP + L-histidine + tRNAHis
-
 Caulobacter vibrioides AMP + diphosphate + L-histidyl-tRNAHis
-
 ?
ATP + L-histidine + tRNAHis best substrate Caulobacter vibrioides AMP + diphosphate + L-histidyl-tRNAHis
-
 ?
additional information no activity with DL-alpha-methyl-histidine, benzyl-L-histidine, 3-[4-thiazolyl]-L-alanine, 2-[thiazolyl]-L-alanine, 1,2,4-triazole-alanine, 2-furyl-L-alanine, 3-cyclopentane-L-alanine, and [3-thienyl]-DL-alanine Caulobacter vibrioides ?
-
 ?

Synonyms

Synonyms Comment Organism
HisRS
-
 Caulobacter vibrioides
Histidyl-tRNA synthetase
-
 Caulobacter vibrioides

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Caulobacter vibrioides