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Literature summary for 6.1.1.20 extracted from
- Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns (2010), Structure, 18, 343-353.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| the structure of cytosolic phenylalanyl-tRNA synthetase in complex with phenylalanine is solved to 3.3 A resolution | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| alphaDELTA1-175 | truncated N-terminal domain of the alpha subunit of hcPheRS | Homo sapiens |
| alphaDELTA60-170 | truncated N-terminal domain of the alpha subunit of hcPheRS | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 38200 | - |
alpha-subunit, mutant DELTA1-175, determined by SDS-PAGE | Homo sapiens |
| 45000 | - |
alpha-subunit, mutant DELTA60-170, determined by SDS-PAGE | Homo sapiens |
| 57500 | - |
alpha-subunit, wild-type, determined by SDS-PAGE | Homo sapiens |
| 67000 | - |
beta-subunit, wild-type, determined by SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NSD9 | beta chain | - |
| Homo sapiens | Q9Y285 | alpha chain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-phenylalanine + tRNAPhe | - |
Homo sapiens | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterotetramer | build of two alphabeta heterodimers | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cytosolic phenylalanyl-tRNA synthetase | - |
Homo sapiens |
| cytosolic PheRS | - |
Homo sapiens |
| hcPheRS | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
tRNA aminoacylation assay | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
tRNA aminoacylation assay | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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