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Literature summary for 6.1.1.20 extracted from

  • Targoff, I.N.
    Autoantibodies and their significance in myositis (2008), Curr. Rheumatol. Rep., 10, 333-340.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information the autoantibody anti-Zo, reactive with phenylalanyltransfer RNA synthetase, immunoprecipitates 155 and 140 kD proteins and is common in children but seems to be associated with malignancy in adults, such as the antisynthetase syndrome, i.e. myositis, ILD, Raynaud’s disease, and arthralgias, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
x * 60000, alpha-subunit, + x * 70000, beta-subunit, SDS-PAGE Homo sapiens
70000
-
x * 60000, alpha-subunit, + x * 70000, beta-subunit, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-phenylalanine + tRNAPhe Homo sapiens
-
AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
?
additional information Homo sapiens the autoantibody anti-Zo, reactive with phenylalanyltransfer RNA synthetase, immunoprecipitates 155 and 140 kD proteins and is common in children but seems to be associated with malignancy in adults, such as the antisynthetase syndrome, i.e. myositis, ILD, Raynaud's disease, and arthralgias, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
Homo sapiens
-
muscle
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-phenylalanine + tRNAPhe
-
Homo sapiens AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
?
additional information the autoantibody anti-Zo, reactive with phenylalanyltransfer RNA synthetase, immunoprecipitates 155 and 140 kD proteins and is common in children but seems to be associated with malignancy in adults, such as the antisynthetase syndrome, i.e. myositis, ILD, Raynaud's disease, and arthralgias, overview Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 60000, alpha-subunit, + x * 70000, beta-subunit, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Phenylalanyl-transfer RNA synthetase
-
Homo sapiens
Phenylalanyl-tRNA synthetase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens