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Literature summary for 6.1.1.20 extracted from
- New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity (2004), Antimicrob. Agents Chemother., 48, 525-532.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chloramphenicol | - |
Haemophilus influenzae |  |
| chloramphenicol | - |
Moraxella catarrhalis | |
| chloramphenicol | - |
Staphylococcus aureus | |
| chloramphenicol | - |
Streptococcus pneumoniae | |
| Methicillin | - |
Haemophilus influenzae | |
| Methicillin | - |
Moraxella catarrhalis | |
| Methicillin | - |
Staphylococcus aureus | |
| Methicillin | - |
Streptococcus pneumoniae | |
| muciproin | - |
Escherichia coli | |
| muciproin | - |
Haemophilus influenzae | |
| muciproin | - |
Moraxella catarrhalis | |
| muciproin | - |
Staphylococcus aureus | |
| muciproin | - |
Streptococcus pneumoniae | |
| phenyl-thiazolylurea-sulfonamides | strong inhibition, several derivatives, competitive to L-phenylalanine | Escherichia coli | |
| phenyl-thiazolylurea-sulfonamides | strong inhibition, several derivatives, competitive to L-phenylalanine, cytotoxic effect | Haemophilus influenzae | |
| phenyl-thiazolylurea-sulfonamides | strong inhibition, several derivatives, competitive to L-phenylalanine, cytotoxic effect | Moraxella catarrhalis | |
| phenyl-thiazolylurea-sulfonamides | strong inhibition, several derivatives, competitive to L-phenylalanine, cytotoxic effect | Staphylococcus aureus | |
| phenyl-thiazolylurea-sulfonamides | strong inhibition, several derivatives, competitive to L-phenylalanine, cytotoxic effect | Streptococcus pneumoniae | |
| phenyl-thiazolylurea-sulfonamido-aminoethyl-chloroindol | - |
Haemophilus influenzae | |
| phenyl-thiazolylurea-sulfonamido-aminoethyl-chloroindol | - |
Moraxella catarrhalis | |
| phenyl-thiazolylurea-sulfonamido-aminoethyl-chloroindol | - |
Staphylococcus aureus | |
| phenyl-thiazolylurea-sulfonamido-aminoethyl-chloroindol | - |
Streptococcus pneumoniae | |
| phenyl-thiazolylurea-sulfonamido-aminoethyl-chloroindole | - |
Escherichia coli | |
| phenyl-thiazolylurea-sulfonamido-aminoethylindol | strong inhibition, competitive to L-phenylalanine, cytotoxic effects on CHO cells and bacteria | Haemophilus influenzae | |
| phenyl-thiazolylurea-sulfonamido-aminoethylindol | strong inhibition, competitive to L-phenylalanine, cytotoxic effects on CHO cells and bacteria | Moraxella catarrhalis | |
| phenyl-thiazolylurea-sulfonamido-aminoethylindol | strong inhibition, competitive to L-phenylalanine, cytotoxic effects on CHO cells and bacteria | Staphylococcus aureus | |
| phenyl-thiazolylurea-sulfonamido-aminoethylindol | strong inhibition, competitive to L-phenylalanine, cytotoxic effects on CHO cells and bacteria | Streptococcus pneumoniae | |
| phenyl-thiazolylurea-sulfonamido-aminoethylindole | strong inhibition, competitive to L-phenylalanine, cytotoxic effects on CHO cells and bacteria | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-phenylalanine + tRNAPhe | Staphylococcus aureus | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | Haemophilus influenzae | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | Escherichia coli | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | Streptococcus pneumoniae | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | Moraxella catarrhalis | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | Staphylococcus aureus 133 | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | Streptococcus pneumoniae G9A | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | Moraxella catarrhalis 489 | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | Haemophilus influenzae Spain 7 | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
purified enzyme, strain CP78 and mutant relA- strain CP79 | - |
| Haemophilus influenzae | - |
clinical isolate | - |
| Haemophilus influenzae Spain 7 | - |
clinical isolate | - |
| Moraxella catarrhalis | - |
- |
- |
| Moraxella catarrhalis 489 | - |
- |
- |
| Staphylococcus aureus | - |
- |
- |
| Staphylococcus aureus 133 | - |
- |
- |
| Streptococcus pneumoniae | - |
- |
- |
| Streptococcus pneumoniae G9A | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-phenylalanine + tRNAPhe | - |
Staphylococcus aureus | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | - |
Haemophilus influenzae | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | - |
Escherichia coli | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | - |
Streptococcus pneumoniae | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | - |
Moraxella catarrhalis | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | - |
Staphylococcus aureus 133 | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | - |
Streptococcus pneumoniae G9A | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | - |
Moraxella catarrhalis 489 | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
| ATP + L-phenylalanine + tRNAPhe | - |
Haemophilus influenzae Spain 7 | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CML33 | - |
Staphylococcus aureus |
| CML33 | - |
Haemophilus influenzae |
| CML33 | - |
Escherichia coli |
| CML33 | - |
Streptococcus pneumoniae |
| CML33 | - |
Moraxella catarrhalis |
| FRS | - |
Staphylococcus aureus |
| FRS | - |
Haemophilus influenzae |
| FRS | - |
Escherichia coli |
| FRS | - |
Streptococcus pneumoniae |
| FRS | - |
Moraxella catarrhalis |
| HSPC173 | - |
Staphylococcus aureus |
| HSPC173 | - |
Haemophilus influenzae |
| HSPC173 | - |
Escherichia coli |
| HSPC173 | - |
Streptococcus pneumoniae |
| HSPC173 | - |
Moraxella catarrhalis |
| L-Phenylalanyl-tRNA synthetase | - |
Staphylococcus aureus |
| L-Phenylalanyl-tRNA synthetase | - |
Haemophilus influenzae |
| L-Phenylalanyl-tRNA synthetase | - |
Escherichia coli |
| L-Phenylalanyl-tRNA synthetase | - |
Streptococcus pneumoniae |
| L-Phenylalanyl-tRNA synthetase | - |
Moraxella catarrhalis |
| Phenylalanine translase | - |
Staphylococcus aureus |
| Phenylalanine translase | - |
Haemophilus influenzae |
| Phenylalanine translase | - |
Escherichia coli |
| Phenylalanine translase | - |
Streptococcus pneumoniae |
| Phenylalanine translase | - |
Moraxella catarrhalis |
| Phenylalanine--tRNA ligase | - |
Staphylococcus aureus |
| Phenylalanine--tRNA ligase | - |
Haemophilus influenzae |
| Phenylalanine--tRNA ligase | - |
Escherichia coli |
| Phenylalanine--tRNA ligase | - |
Streptococcus pneumoniae |
| Phenylalanine--tRNA ligase | - |
Moraxella catarrhalis |
| Phenylalanine-tRNA synthetase | - |
Staphylococcus aureus |
| Phenylalanine-tRNA synthetase | - |
Haemophilus influenzae |
| Phenylalanine-tRNA synthetase | - |
Escherichia coli |
| Phenylalanine-tRNA synthetase | - |
Streptococcus pneumoniae |
| Phenylalanine-tRNA synthetase | - |
Moraxella catarrhalis |
| Phenylalanyl transfer ribonucleic acid synthetase | - |
Staphylococcus aureus |
| Phenylalanyl transfer ribonucleic acid synthetase | - |
Haemophilus influenzae |
| Phenylalanyl transfer ribonucleic acid synthetase | - |
Escherichia coli |
| Phenylalanyl transfer ribonucleic acid synthetase | - |
Streptococcus pneumoniae |
| Phenylalanyl transfer ribonucleic acid synthetase | - |
Moraxella catarrhalis |
| Phenylalanyl-transfer ribonucleate synthetase | - |
Staphylococcus aureus |
| Phenylalanyl-transfer ribonucleate synthetase | - |
Haemophilus influenzae |
| Phenylalanyl-transfer ribonucleate synthetase | - |
Escherichia coli |
| Phenylalanyl-transfer ribonucleate synthetase | - |
Streptococcus pneumoniae |
| Phenylalanyl-transfer ribonucleate synthetase | - |
Moraxella catarrhalis |
| Phenylalanyl-transfer RNA ligase | - |
Staphylococcus aureus |
| Phenylalanyl-transfer RNA ligase | - |
Haemophilus influenzae |
| Phenylalanyl-transfer RNA ligase | - |
Escherichia coli |
| Phenylalanyl-transfer RNA ligase | - |
Streptococcus pneumoniae |
| Phenylalanyl-transfer RNA ligase | - |
Moraxella catarrhalis |
| Phenylalanyl-transfer RNA synthetase | - |
Staphylococcus aureus |
| Phenylalanyl-transfer RNA synthetase | - |
Haemophilus influenzae |
| Phenylalanyl-transfer RNA synthetase | - |
Escherichia coli |
| Phenylalanyl-transfer RNA synthetase | - |
Streptococcus pneumoniae |
| Phenylalanyl-transfer RNA synthetase | - |
Moraxella catarrhalis |
| Phenylalanyl-tRNA ligase | - |
Staphylococcus aureus |
| Phenylalanyl-tRNA ligase | - |
Haemophilus influenzae |
| Phenylalanyl-tRNA ligase | - |
Escherichia coli |
| Phenylalanyl-tRNA ligase | - |
Streptococcus pneumoniae |
| Phenylalanyl-tRNA ligase | - |
Moraxella catarrhalis |
| Phenylalanyl-tRNA synthetase | - |
Staphylococcus aureus |
| Phenylalanyl-tRNA synthetase | - |
Haemophilus influenzae |
| Phenylalanyl-tRNA synthetase | - |
Escherichia coli |
| Phenylalanyl-tRNA synthetase | - |
Streptococcus pneumoniae |
| Phenylalanyl-tRNA synthetase | - |
Moraxella catarrhalis |
| PheRS | - |
Staphylococcus aureus |
| PheRS | - |
Haemophilus influenzae |
| PheRS | - |
Escherichia coli |
| PheRS | - |
Streptococcus pneumoniae |
| PheRS | - |
Moraxella catarrhalis |
| Synthetase, phenylalanyl-transfer ribonucleate | - |
Staphylococcus aureus |
| Synthetase, phenylalanyl-transfer ribonucleate | - |
Haemophilus influenzae |
| Synthetase, phenylalanyl-transfer ribonucleate | - |
Escherichia coli |
| Synthetase, phenylalanyl-transfer ribonucleate | - |
Streptococcus pneumoniae |
| Synthetase, phenylalanyl-transfer ribonucleate | - |
Moraxella catarrhalis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Staphylococcus aureus | |
| ATP | - |
Haemophilus influenzae | |
| ATP | - |
Escherichia coli | |
| ATP | - |
Streptococcus pneumoniae | |
| ATP | - |
Moraxella catarrhalis | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Staphylococcus aureus | |
| additional information | - |
additional information | - |
Haemophilus influenzae | |
| additional information | - |
additional information | - |
Escherichia coli | |
| additional information | - |
additional information | - |
Streptococcus pneumoniae | |
| additional information | - |
additional information | - |
Moraxella catarrhalis | |
| 0.000021 | - |
phenyl-thiazolylurea-sulfonamido-aminoethylindole | pH 7.6, 22°C | Escherichia coli | |
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