Literature summary for 6.1.1.2 extracted from

Wakasugi, K.; Nakano, T.; Morishima, I.
Oxidative stress-responsive intracellular regulation specific for the angiostatic form of human tryptophanyl-tRNA synthetase (2005), Biochemistry, 44, 225-232.

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Activating Compound

Activating Compound	Comment	Organism	Structure
glyceraldehyde 3-phosphate dehydrogenase	the oxidized form of glyceraldehyde 3-phosphate dehydrogenase interacts with both full-length and mini tryptophanyl-tRNA synthetase and specifically stimulates the aminoacylation potential of mini, but not full-length tryptophanyl-tRNA synthetase. In contrast, reduced glyceraldehyde 3-phosphate dehydrogenase does not bind to tryptophanyl-tRNA synthetase and does not influence their aminoacylation activity	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-tryptophan + tRNATrp	human mini, but not full-length, tryptophanyl-tRNA synthetase may play an important role in the intracellular regulation of protein synthesis under conditions of oxidative stress	Homo sapiens	AMP + diphosphate + L-tryptophan-tRNATrp	-	?

Synonyms

Synonyms	Comment	Organism
TrpRS	-	Homo sapiens

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Release 2023.1 (January 2023)