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Literature summary for 6.1.1.18 extracted from
- A cognate tRNA specific conformational change in glutaminyl-tRNA synthetase and its implication for specificity (1998), Protein Sci., 7, 1046-1051.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-glutamine + tRNAGln | Escherichia coli | - |
AMP + diphosphate + L-glutaminyl-tRNAGln | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + L-glutamine + tRNAGln = AMP + diphosphate + L-glutaminyl-tRNAGln | binding of ATP and of tRNAGln induces conformational changes that change the interaction of the enzyme with the cognate tRNA, crucial for substrate recognition and selectivity | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-glutamine + tRNAGln | - |
Escherichia coli | AMP + diphosphate + L-glutaminyl-tRNAGln | - |
? | |
| additional information | conformational changes are induced by tRNAGln binding not by binding of tRNAGlu | Escherichia coli | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GlnRS | - |
Escherichia coli |
| Glutaminyl-tRNA synthetase | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | binding of ATP induces conformational changes that change the interaction of the enzyme with the cognate tRNA | Escherichia coli | |
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Release 2023.1 (January 2023)
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