Literature summary for 6.1.1.18 extracted from

Bernier, S.; Dubois, D.Y.; Therrien, M.; Lapointe, J.; Chenevert, R.
Synthesis of glutaminyl adenylate analogues that are inhibitors of glutaminyl-tRNA synthetase (2000), Bioorg. Med. Chem. Lett., 10, 2441-2444.

Search for more literature for 6.1.1.18

Inhibitors

Inhibitors	Comment	Organism	Structure
5'-O-[N-(L-glutaminyl)sulfamoyl] adenosine	i.e. QSI, competitive to glutamine	Escherichia coli
glutaminol adenylate	competitive to glutamine	Escherichia coli
glutaminol adenylate methyl phosphate ester	competitive to glutamine	Escherichia coli

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-glutamine + tRNAGln	Escherichia coli	-	AMP + diphosphate + L-glutaminyl-tRNAGln	-	r

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-glutamine + tRNAGln	-	Escherichia coli	AMP + diphosphate + L-glutaminyl-tRNAGln	-	r
ATP + L-glutamine + tRNAGln	two-step reaction: 1. recognition of appropriate amino acid by the enzyme and formation of an enzyme-bound mixed anhydride, the aminoacyl-AMP, under release of diphosphate, 2. transfer of the activated amino acid to the CCA end of the cognate tRNA to form aminoacyl-tRNA and AMP, both steps are tRNA-dependent	Escherichia coli	AMP + diphosphate + L-glutaminyl-tRNAGln	-	r

Synonyms

Synonyms	Comment	Organism
GlnRS	-	Escherichia coli
Glutaminyl-tRNA synthetase	-	Escherichia coli

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Escherichia coli

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00028	-	glutaminol adenylate	versus glutamine	Escherichia coli
0.0013	-	5'-O-[N-(L-glutaminyl)sulfamoyl] adenosine	versus glutamine	Escherichia coli
0.01	-	glutaminol adenylate methyl phosphate ester	versus glutamine	Escherichia coli

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Release 2023.1 (January 2023)