Literature summary for 6.1.1.17 extracted from

Liu, J.; Gagnon, Y.; Gauthier, J.; Furenlid, L.; L'Heureux, P.J.; Auger, M.; Nureki, O.; Yokoyama, S.; Lapointe, J.
The zinc-binding site of Escherichia coli glutamyl-tRNA synthetase is located in the acceptor-binding domain (1995), J. Biol. Chem., 270, 15162-15169.

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Protein Variants

Protein Variants	Comment	Organism
H129Q	mutants encoding GluRS variants altered in the 98C-138C segment. Thermosensitive mutants H129Q, H131Q, H132Q and C138S. Mutants without glutamyl-tRNA synthetase activity: C100S, C125S. In the mutants C98S and H127Q the activity is 10fold lower than in cells overproducing the wild-type enzyme or the variants H129Q, H131Q, H132Q, and C138S	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	mutants encoding GluRS variants altered in the 98C-138C segment	-

Purification (Commentary)

Purification (Comment)	Organism
-	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-glutamate + tRNAGlu	-	Escherichia coli	AMP + diphosphate + L-glutamyl-tRNAGlu	-	?

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Release 2023.1 (January 2023)