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Literature summary for 6.1.1.16 extracted from
- Editing function of Escherichia coli cysteinyl-tRNA synthetase: cyclization of cysteine to cysteine thiolactone (1994), Nucleic Acids Res., 22, 1155-1160.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cys-AMP | inhibits deacylation of Cys-tRNACys | Escherichia coli |  |
| cysteine | inhibits deacylation of Cys-tRNACys | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AMP + diphosphate + L-cysteinyl-tRNACys | - |
Escherichia coli | ATP + L-cysteine + tRNACys | - |
r | |
| ATP + L-cysteine + tRNACys | - |
Escherichia coli | AMP + diphosphate + L-cysteinyl-tRNACys | - |
? | |
| L-Cysteinyl-tRNACys | deacylation in which nucleophilic sulfur of the side chain of cysteine in Cys-tRNACys attacks its carboxyl carbon, synthesis of Cys-tRNACys and cyclization of cysteine to thiolactone occur in a single active site | Escherichia coli | Cysteine thiolactone + ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.017 | - |
L-Cysteinyl-tRNACys | - |
Escherichia coli | |
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