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Literature summary for 6.1.1.15 extracted from

  • Praetorius-Ibba, M.; Rogers, T.E.; Samson, R.; Kelman, Z.; Ibba, M.
    Association between Archaeal prolyl- and leucyl-tRNA synthetases enhances tRNA(Pro) aminoacylation (2005), J. Biol. Chem., 280, 26099-26104.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.15

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0014
-
 tRNAPro presence of bovine serum albumine and leucyl-tRNA synthetase, 50°C, pH 7.5 Methanothermobacter thermautotrophicus
0.0022
-
 tRNAPro presence of leucyl-tRNA synthetase, 50°C, pH 7.5 Methanothermobacter thermautotrophicus
0.0024
-
 tRNAPro presence of bovine serum albumine, 50°C, pH 7.5 Methanothermobacter thermautotrophicus
0.0041
-
 tRNAPro 50°C, pH 7.5 Methanothermobacter thermautotrophicus
0.061
-
 L-proline presence of bovine serum albumine and leucyl-tRNA synthetase, 50°C, pH 7.5 Methanothermobacter thermautotrophicus
0.067
-
 L-proline presence of bovine serum albumine, 50°C, pH 7.5 Methanothermobacter thermautotrophicus

Organism

Organism UniProt Comment Textmining
Methanothermobacter thermautotrophicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-proline + tRNAPro
-
 Methanothermobacter thermautotrophicus AMP + diphosphate + L-prolyl-tRNAPro
-
 ?

Subunits

Subunits Comment Organism
More enzyme in vivo interacts with leucyl-tRNA synthetase, increasing its catalytic efficiency 5fold Methanothermobacter thermautotrophicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8
-
 tRNAPro 50°C, pH 7.5 Methanothermobacter thermautotrophicus
2.9
-
 tRNAPro presence of bovine serum albumine, 50°C, pH 7.5 Methanothermobacter thermautotrophicus
5.1
-
 tRNAPro presence of leucyl-tRNA synthetase, 50°C, pH 7.5 Methanothermobacter thermautotrophicus
6.9
-
 tRNAPro presence of bovine serum albumine and leucyl-tRNA synthetase, 50°C, pH 7.5 Methanothermobacter thermautotrophicus