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Literature summary for 6.1.1.11 extracted from

  • Hu, J.; Tian, J.; Li, F.; Xue, B.; Hu, J.; Cheng, X.; Li, J.; Shen, W.; Li, B.
    Clone and functional analysis of seryl-tRNA synthetase and tyrosyl-tRNA synthetase from silkworm, Bombyx mori (2017), Sci. Rep., 7, 41563 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.11

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, sequence comparisons, RT-PCR expression analysis, phylogenetic analysis and tree Bombyx mori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-serine + tRNASer Bombyx mori
-
 AMP + diphosphate + L-seryl-tRNASer
-
 ?

Organism

Organism UniProt Comment Textmining
Bombyx mori
-
 variety Jingsong x Haoyue
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Bombyx mori A0A1Q1NKM3 var. Jingsong x Haoyue
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information tissue expression analysis of enzyme TyrRS, the transcription level of TyrRS is significantly higher in silk gland than in other tissues Bombyx mori
-
silk gland
-
 Bombyx mori
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silk gland transcription levels are much higher in middle and posterior silk gland than in anterior silk gland Bombyx mori
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-serine + tRNASer
-
 Bombyx mori AMP + diphosphate + L-seryl-tRNASer
-
 ?

Synonyms

Synonyms Comment Organism
SerRS
-
 Bombyx mori
Seryl-tRNA synthetase
-
 Bombyx mori

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Bombyx mori

Expression

Organism Comment Expression
Bombyx mori treatment of silkworms with phoxim, an inhibitor of silk protein synthesis, but not TiO2 NP, an enhancer of silk protein synthesis, significantly reduce the transcription levels of aminoacyl-tRNA synthetases and content of free amino acids in posterior silk gland, therefore affecting silk protein synthesis, which may be the mechanism of phoxim-silking disorders. Low concentration of TiO2 NPs shows no effect on the transcription of aminoacyl-tRNA synthetases and content of free amino acids, suggesting that TiO2 NPs promotes silk protein synthesis possibly by increasing the activity of fibroin synthase in silkworm down

General Information

General Information Comment Organism
evolution SerRS belongs to the class II aminoacyl-tRNA synthetases (aaRSs), evolutionary analysis of SerRS and TyrRS, overview Bombyx mori
physiological function aminoacyl-tRNA synthetases (aaRSs) for glycine, alanine, serine and tyrosine play important roles in fibroin synthesis Bombyx mori