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Literature summary for 6.1.1.11 extracted from

  • Battenberg, O.A.; Yang, Y.; Verhelst, S.H.; Sieber, S.A.
    Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification (2013), Mol. Biosyst., 9, 343-351.
    View publication on PubMed
Search for more literature for 6.1.1.11

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
(E)-3-(3-ethynyl-4-hydroxyphenyl)-1-(2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)prop-2-en-1-one
-
 Staphylococcus aureus
4-hydroxyderricin
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-serine + tRNASer Staphylococcus aureus
-
 AMP + diphosphate + L-seryl-tRNASer
-
 ?
ATP + L-serine + tRNASer Staphylococcus aureus NCTC 8325
-
 AMP + diphosphate + L-seryl-tRNASer
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus NCTC 8325
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-serine + tRNASer
-
 Staphylococcus aureus AMP + diphosphate + L-seryl-tRNASer
-
 ?
ATP + L-serine + tRNASer
-
 Staphylococcus aureus NCTC 8325 AMP + diphosphate + L-seryl-tRNASer
-
 ?

Synonyms

Synonyms Comment Organism
Seryl-tRNA synthetase
-
 Staphylococcus aureus
STS
-
 Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Staphylococcus aureus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0238
-
 in 100 mM HEPES (pH 7.2), 10 mM MgCl2, 30 mM KCl, at 37°C Staphylococcus aureus (E)-3-(3-ethynyl-4-hydroxyphenyl)-1-(2-hydroxy-4-methoxy-3-(3-methylbut-2-en-1-yl)phenyl)prop-2-en-1-one