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Literature summary for 6.1.1.11 extracted from

  • Ahel, D.; Slade, D.; Mocibob, M.; Soll, D.; Weygand-Durasevic, I.
    Selective inhibition of divergent seryl-tRNA synthetases by serine analogues (2005), FEBS Lett., 579, 4344-4348.
    View publication on PubMed
Search for more literature for 6.1.1.11

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Methanosarcina barkeri

Inhibitors

Inhibitors Comment Organism Structure
serinamide inhibition of methanogenic type seryl-tRNA synthetase, no inhibition of bacterial type seryl-tRNA synthetase Methanosarcina barkeri
serine hydroxamate
-
 Methanosarcina barkeri
serine methyl ester
-
 Methanosarcina barkeri

Organism

Organism UniProt Comment Textmining
Methanosarcina barkeri
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-serine + tRNASer
-
 Methanosarcina barkeri AMP + diphosphate + L-seryl-tRNASer
-
 ?

Synonyms

Synonyms Comment Organism
bacterial type seryl-tRNA synthetase
-
 Methanosarcina barkeri
methanogenic type seryl-tRNA synthetase
-
 Methanosarcina barkeri
SerRS
-
 Methanosarcina barkeri

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0032
-
 serinamide methanogenic type seryl-tRNA synthetase Methanosarcina barkeri
0.18
-
 serine hydroxamate methanogenic type seryl-tRNA synthetase Methanosarcina barkeri
0.55
-
 serine methyl ester methanogenic type seryl-tRNA synthetase Methanosarcina barkeri
1
-
 serinamide bacterial type seryl-tRNA synthetase Methanosarcina barkeri
1.6
-
 serine hydroxamate bacterial type seryl-tRNA synthetase Methanosarcina barkeri
3.5
-
 serine methyl ester bacterial type seryl-tRNA synthetase Methanosarcina barkeri