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Literature summary for 6.1.1.10 extracted from

  • Bharathkumar, H.; Mohan, C.D.; Rangappa, S.; Kang, T.; Keerthy, H.K.; Fuchs, J.E.; Kwon, N.H.; Bender, A.; Kim, S.; Basappa, S.; Rangappa, K.S.
    Screening of quinoline, 1,3-benzoxazine, and 1,3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in silico binding mode analysis (2015), Org. Biomol. Chem., 13, 9381-9387 .
    View publication on PubMed
Search for more literature for 6.1.1.10

Inhibitors

Inhibitors Comment Organism Structure
2-(1H-indol-3-yl)-1,4-dihydro-2H-3,1-benzoxazine
-
 Homo sapiens
2-(1H-indol-3-yl)-5-(4-methoxyphenyl)-1-oxa-3-azaspiro[5.5]undecane
-
 Homo sapiens
2-(2,3-dihydroquinolin-2-yl)phenol
-
 Homo sapiens
2-(2,4-dichlorophenyl)-6-methylquinoline
-
 Homo sapiens
2-(2,4-dichlorophenyl)quinoline
-
 Homo sapiens
2-(2,6-difluorophenyl)-5-(4-methoxyphenyl)-1-oxa-3-azaspiro[5.5]undecane
-
 Homo sapiens
2-(2-bromophenyl)-6-methyl-2,3-dihydroquinoline
-
 Homo sapiens
2-(2-butyl-4-chloro-1-(4-nitrobenzyl)-1H-imidazol-5-yl)-2,4-dihydro-1Hbenzo[d][1,3]oxazine
-
 Homo sapiens
2-(2-butyl-4-chloro-1-(4-phenoxybenzyl)-1H-imidazol-5-yl)-5-(4-methoxyphenyl)-1-oxa-3-azaspiro[5.5]undecane
-
 Homo sapiens
2-(2-butyl-4-chloro-1H-imidazol-5-yl)-1,4-dihydro-2H-3,1-benzoxazine
-
 Homo sapiens
2-(2-butyl-4-chloro-1H-imidazol-5-yl)-5-(4-methoxyphenyl)-1-oxa-3-azaspiro[5.5]undecane
-
 Homo sapiens
2-(4-bromophenyl)-5-(4-methoxyphenyl)-1-oxa-3-azaspiro[5.5]undecane
-
 Homo sapiens
3-(1,4-dihydro-2H-3,1-benzoxazin-2-yl)-4H-1-benzopyran-4-one
-
 Homo sapiens
3-(5-(4-methoxyphenyl)-1-oxa-3-azaspiro[5.5]undecan-2-yl)-4H-chromen-4-one
-
 Homo sapiens
3-(6-chloro-1,4-dihydro-2H-3,1-benzoxazin-2-yl)-4H-1-benzopyran-4-one
-
 Homo sapiens
3-(6-methyl-1,4-dihydro-2H-3,1-benzoxazin-2-yl)-4H-1-benzopyran-4-one
-
 Homo sapiens
4'-((2-butyl-4-chloro-5-(5-(4-methoxyphenyl)-1-oxa-3-azaspiro[5.5]undecan-2-yl)-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-carbonitrile
-
 Homo sapiens
4'-[(3-[5-[4-(hydroxymethyl)phenyl]-1-oxa-3-azaspiro[5.5]undecan-2-yl]-2,3-dihydro-1H-indol-1-yl)methyl][1,1'-biphenyl]-2-carbonitrile
-
 Homo sapiens
4'-[[3-(1,4-dihydro-2H-3,1-benzoxazin-2-yl)-1H-indol-1-yl]methyl][1,1'-biphenyl]-2-carbonitrile
-
 Homo sapiens
4-(1,4-dihydro-2H-3,1-benzoxazin-2-yl)phenol
-
 Homo sapiens
4-(5-(4-methoxyphenyl)-1-oxa-3-azaspiro[5.5]undecan-2-yl)-N,Ndimethylaniline
-
 Homo sapiens
4-(6-chloroquinolin-2-yl)aniline
-
 Homo sapiens
4-(7-chloro-1,4-dihydro-2H-3,1-benzoxazin-2-yl)phenol
-
 Homo sapiens
5-(4-methoxyphenyl)-2-(2-methyl-1H-indol-3-yl)-1-oxa-3-azaspiro[5.5]undecane
-
 Homo sapiens
5-(4-methoxyphenyl)-2-(2-phenyl-1H-indol-3-yl)-1-oxa-3-azaspiro[5.5]undecane
-
 Homo sapiens
6-chloro-2-(1H-indol-3-yl)-1,4-dihydro-2H-3,1-benzoxazine
-
 Homo sapiens
6-chloro-2-(2-phenyl-1H-indol-3-yl)-1,4-dihydro-2H-3,1-benzoxazine
-
 Homo sapiens
6-methyl-2-(2-methyl-1H-indol-3-yl)-1,4-dihydro-2H-3,1-benzoxazine
-
 Homo sapiens
6-methyl-2-(2-phenyl-1H-indol-3-yl)-1,4-dihydro-2H-3,1-benzoxazine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + tRNAMet Homo sapiens
-
 AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + tRNAMet
-
 Homo sapiens AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Synonyms

Synonyms Comment Organism
methionyl-tRNA synthetase
-
 Homo sapiens
MRS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens