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Literature summary for 6.1.1.10 extracted from

  • Hussain, T.; Yogavel, M.; Sharma, A.
    Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases (2015), Antimicrob. Agents Chemother., 59, 1856-1867 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.10

Inhibitors

Inhibitors Comment Organism Structure
1,4-anhydro-2-bromo-2,3,5-trideoxy-1-(1-fluoroethenyl)-3-methyl-5-([3-[(4-oxo-1,4-dihydroquinolin-2-yl)amino]propyl]amino)-1-thiopentitol
-
 Plasmodium falciparum
2-([2-[([2-[(2-fluorophenyl)methoxy]naphthalen-1-yl]methyl)amino]ethyl]amino)ethan-1-ol
-
 Plasmodium falciparum
2-([2-[([2-[(4-fluorophenyl)methoxy]naphthalen-1-yl]methyl)amino]ethyl]amino)ethan-1-ol
-
 Plasmodium falciparum
2-[([2-[(4-fluorophenyl)methoxy]naphthalen-1-yl]methyl)amino]ethan-1-ol
-
 Plasmodium falciparum
2-[[2-([[2-(benzyloxy)naphthalen-1-yl]methyl]amino)ethyl]amino]ethan-1-ol
-
 Plasmodium falciparum
3-[[(4-chloronaphthalen-1-yl)oxy]methyl]piperidine
-
 Plasmodium falciparum
4-(1H-benzimidazol-2-yl)-N-[(2-chloro-6-fluorophenyl)methyl]aniline
-
 Plasmodium falciparum
4-(1H-benzimidazol-2-yl)-N-[(3-chlorophenyl)methyl]aniline
-
 Plasmodium falciparum
4-(1H-benzimidazol-2-yl)-N-[(4-chlorophenyl)methyl]aniline
-
 Plasmodium falciparum
5-([3-[(6,8-dibromo-3,4-dihydro-2H-1-benzopyran-4-yl)amino]propyl]amino)thieno[3,2-b]pyridin-7(4H)-one
-
 Plasmodium falciparum
anisomycin
-
 Plasmodium falciparum
REP3123
-
 Plasmodium falciparum
REP8839
-
 Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
apicoplast
-
 Plasmodium falciparum 20011
-
cytoplasm
-
 Plasmodium falciparum 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + tRNAMet Plasmodium falciparum
-
 AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + tRNAMet
-
 Plasmodium falciparum AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Synonyms

Synonyms Comment Organism
methionyl-tRNA synthetase
-
 Plasmodium falciparum
MRSapi isoform Plasmodium falciparum
MRScyt isoform Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000144
-
 at pH 7.5 and 37°C Plasmodium falciparum 5-([3-[(6,8-dibromo-3,4-dihydro-2H-1-benzopyran-4-yl)amino]propyl]amino)thieno[3,2-b]pyridin-7(4H)-one
0.000146
-
 at pH 7.5 and 37°C Plasmodium falciparum REP3123
0.000155
-
 at pH 7.5 and 37°C Plasmodium falciparum 1,4-anhydro-2-bromo-2,3,5-trideoxy-1-(1-fluoroethenyl)-3-methyl-5-([3-[(4-oxo-1,4-dihydroquinolin-2-yl)amino]propyl]amino)-1-thiopentitol
0.000177
-
 at pH 7.5 and 37°C Plasmodium falciparum 4-(1H-benzimidazol-2-yl)-N-[(2-chloro-6-fluorophenyl)methyl]aniline
0.000281
-
 at pH 7.5 and 37°C Plasmodium falciparum REP8839
0.000293
-
 at pH 7.5 and 37°C Plasmodium falciparum 2-([2-[([2-[(4-fluorophenyl)methoxy]naphthalen-1-yl]methyl)amino]ethyl]amino)ethan-1-ol
0.000303
-
 at pH 7.5 and 37°C Plasmodium falciparum 3-[[(4-chloronaphthalen-1-yl)oxy]methyl]piperidine
0.074
-
 at pH 7.5 and 37°C Plasmodium falciparum anisomycin