Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.10 extracted from

  • Farhanullah, R.J.; Kim, S.Y.; Yoon, E.J.; Choi, E.C.; Kim, S.; Kang, T.; Samrin, F.; Puri, S.; Lee, J.
    Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors (2006), Bioorg. Med. Chem., 14, 7154-7159.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-[3-(3,4-dichlorobenzylamino)-1-hydroxymethylpropylamino]-1H-quinolin-4-one
-
Staphylococcus aureus
2-[3-(3,4-dichlorobenzylamino)-2-hydroxypropylamino]-1H-quinolin-4-one
-
Staphylococcus aureus
2-[3-(3,4-dichlorobenzylamino)-2-methoxypropylamino]-1H-quinolin-4-one
-
Staphylococcus aureus
2-[3-(3,4-dichlorobenzylamino)-4-hydroxybutylamino]-1H-quinolin-4-one
-
Staphylococcus aureus
2-[3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one
-
Staphylococcus aureus
4-[3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-2-one
-
Staphylococcus aureus
additional information in vitro minimum inhibitory concentrations of quinoline compounds with different strains of Staphylococcus aureus, structure-activity relationships Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Synonyms

Synonyms Comment Organism
methionyl-tRNA synthetase
-
Staphylococcus aureus
MRS
-
Staphylococcus aureus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000011
-
isozyme MRSA Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one
0.0000023
-
-
Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-2-hydroxypropylamino]-1H-quinolin-4-one
0.0000025
-
-
Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-2-methoxypropylamino]-1H-quinolin-4-one
0.0000029
-
-
Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-4-hydroxybutylamino]-1H-quinolin-4-one
0.0000186
-
-
Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-1-hydroxymethylpropylamino]-1H-quinolin-4-one
0.00495
-
-
Staphylococcus aureus 4-[3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-2-one