Literature summary for 6.1.1.1 extracted from

Ling, Z.; Yanling, Z.; Zhe, F.; Kui, C.; Xiushi, Z.; Min, Y.; Wei, M.
Recombinant human tyrosyl-tRNA synthetase, a novel thrombopoietic agent (2014), Eur. J. Pharmacol., 738, 293-300 .

Search for more literature for 6.1.1.1

Application

Application	Comment	Organism
medicine	recombinant hTyrRS might be a useful therapeutic agent for chemotherapy-induced thrombocytopenia. Intraperitoneal administration of at least 0.01 mg/day recombinant hTyrRS for 7 days significantly prevents the decrease in platelets 8 days after cyclophosphamide injection	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
hTyrRS	-	Homo sapiens
Tyrosyl-tRNA synthetase	-	Homo sapiens
TyrRS	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	adhesion assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	adhesion assay at	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the human TyrRS can be split into two fragments with distinct signaling activities. The N-terminal fragment is an IL-8-like cytokine whereas the C-terminal fragment is more similar to endothelial monocyte-activating polypeptide II (EMAP II). Therapeutic effect of recombinant human tyrosyl-tRNA synthetase (rhTyrRS) against development of thrombocytopenia in cyclophosphamide (CTX) treated mice. Recombinant hTyrRS promotes migration and aggregation of megakaryocytes to the bone marrow niche. 1 is particularly important for the adhesion. The N-terminal fragment of the recombinant TyrRS acts as a chemoattractant molecule for M-07e cells, it stimulates adhesion of THP-1 cells to HUVECs and plays a role in the transendothelial migration of megakaryocytes and thrombocytopoiesis. All mice pretreated with rhTyrRS show a dose-dependent increase in megakaryocytes localized to the sinusoids. Recombinant human TyrRS enhances survival of cyclophosphamide (CTX) treated mice, that the bone marrow endothelial cells may enhance survival of megakaryocytes in the presence of rhTyrRS pretreatment	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)