Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(3,4-dichlorophenyl)-4-(2-(4-methylpiperazin-1-yl)ethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-(3,4-difluorophenyl)-4-(2-(piperidin-1-yl)ethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-(3,4-dimethoxyphenyl)-4-(2-(4-methylpiperazin-1-yl)ethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-(3,4-dimethoxyphenyl)-4-(2-(piperidin-1-yl)ethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-(3-bromophenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-(3-chlorophenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-(3-hydroxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-(3-methoxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-(4-bromophenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-(4-chlorophenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-(4-hydroxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | replacement of the morpholine-ring in the side chain of the compound with a substituent containing more hydrophilic groups is probably more suitable for further modification. Most potent agent against Staphylococcus aureus ATCC 25923 with MIC50 value of 0.00023 mg/ml | Staphylococcus aureus | |
3-(4-methoxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-phenyl-4-(2-(piperidin-1-yl)ethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-phenyl-4-(2-(propylamino)ethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
3-phenyl-4-(2-(pyrrolidin-1-yl)ethoxy)furan-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(2-(4-nitrophenyl)hydrazinyl)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(4-methylpiperazin-1-yl)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(benzylamino)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(butylamino)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(cyclohexylamino)ethoxy)-3-(3,4-dimethoxyphenyl)furan-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-(cyclohexylamino)ethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
4-(2-morpholinoethoxy)-3-phenylfuran-2(5H)-one | - |
Staphylococcus aureus | |
additional information | synthesis of a series of novel 4-alkoxy-3-arylfuran-2(5H)-ones as tyrosyl-tRNA synthetase inhibitors, binding model and structure-activity relationship, MIC50 values, overview | Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | - |
- |
- |
Staphylococcus aureus ATCC 25923 | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
TyrRS | - |
Staphylococcus aureus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0001 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-(4-hydroxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | |
0.00062 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-(4-chlorophenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | |
0.0024 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-(4-bromophenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | |
0.0062 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 4-(2-morpholinoethoxy)-3-phenylfuran-2(5H)-one | |
0.0086 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 4-(2-(4-methylpiperazin-1-yl)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0205 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-(3-chlorophenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | |
0.0243 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-(3-bromophenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | |
0.0256 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-(3-hydroxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | |
0.0291 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-phenyl-4-(2-(propylamino)ethoxy)furan-2(5H)-one | |
0.0328 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-(4-methoxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | |
0.0355 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-phenyl-4-(2-(pyrrolidin-1-yl)ethoxy)furan-2(5H)-one | |
0.0375 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-(3-methoxyphenyl)-4-(2-morpholinoethoxy)furan-2(5H)-one | |
0.0536 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-phenyl-4-(2-(piperidin-1-yl)ethoxy)furan-2(5H)-one | |
0.0719 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 4-(2-(butylamino)ethoxy)-3-phenylfuran-2(5H)-one | |
0.0874 | - |
pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 4-(2-(cyclohexylamino)ethoxy)-3-phenylfuran-2(5H)-one | |
0.1 | - |
above, pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 4-(2-(benzylamino)ethoxy)-3-phenylfuran-2(5H)-one | |
0.1 | - |
above, pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 4-(2-(2-(4-nitrophenyl)hydrazinyl)ethoxy)-3-phenylfuran-2(5H)-one | |
0.1 | - |
above, pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 4-(2-(cyclohexylamino)ethoxy)-3-(3,4-dimethoxyphenyl)furan-2(5H)-one | |
0.1 | - |
above, pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-(3,4-dimethoxyphenyl)-4-(2-(piperidin-1-yl)ethoxy)furan-2(5H)-one | |
0.1 | - |
above, pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-(3,4-dimethoxyphenyl)-4-(2-(4-methylpiperazin-1-yl)ethoxy)furan-2(5H)-one | |
0.1 | - |
above, pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-(3,4-dichlorophenyl)-4-(2-(4-methylpiperazin-1-yl)ethoxy)furan-2(5H)-one | |
0.1 | - |
above, pH not specified in the publication, temperature not specified in the publication | Staphylococcus aureus | 3-(3,4-difluorophenyl)-4-(2-(piperidin-1-yl)ethoxy)furan-2(5H)-one |