Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | the C-terminal EMAP II-like protein domain of the enzyme is probably responsible for mediation of enzyme export | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + tyrosine + tRNATyr | Homo sapiens | - |
AMP + Tyr-tRNATyr + diphosphate | - |
? | |
additional information | Homo sapiens | the enzyme's C-terminal domain, an EMAP II-like protein, is active in angiogenesis pathways and stimulates immune cells, when cleaved off the enzyme, it stimulates blood vessel development | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
the enzyme's C-terminal domain is a endothelial monocyte activating polypeptide II-like, i.e. an EMAP II-like, protein with cytokine activity | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | the C-terminal domain of the enzyme, which has cytokine and angiogenic activity and stimulates immune cells, is isolated by proteolytic cleavage or alternative splicing, the mini enzyme is a stimulator of blood vessel development, the full-length enzyme is inactive | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + tyrosine + tRNATyr | - |
Homo sapiens | AMP + Tyr-tRNATyr + diphosphate | - |
? | |
additional information | the enzyme's C-terminal domain, an EMAP II-like protein, is active in angiogenesis pathways and stimulates immune cells, when cleaved off the enzyme, it stimulates blood vessel development | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tyrosyl-tRNA synthetase | - |
Homo sapiens |
TyrRS | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |